Endocrine Abstracts

Objective: Insulin-like growth factor 1 (IGF1) is associated with metabolic parameters and involved in glucose metabolism. Low IGF1 has been implicated in the etiology of glucose intolerance. However, epidemiological data are scarce and the role of IGF1 in prospective studies is not clear to date.Research design and methods: We measured IGF1 levels in 7665 subjects free of diabetes from two German prospective cohort studies, the DETECT study and SHIP and...

Introduction: Somatostatin analogues (SSA) present the treatment of choice in patients with previously poorly controlled acromegaly.Methods: We conducted a retrospective analysis of acromegalic patients enrolled in the Network of Excellence for Neuroendocrine Tumors Munich and treated with the SSA lanreotide.Results: Fifty-six acromegalic patients (25 females; mean age 59 years; 33 with macroadenoma) switched to lanreotide from pre...

Introduction: Discontinuation of GH therapy in patients with COGHD after attainment of final height has been associated with impaired somatic development, altered peak bone mass and cardiovascular risk factors. A well-managed transition of care between paediatric and adult health services can improve the clinical and social outcomes in adolescents with GHD.Objective: To assess the quality of the transfer between children and adult medical services in our...

Background: Low testosterone levels in men occur with increasing age and are associated with increased morbidity, particularly metabolic syndrome, and mortality. As the prevalence of hypogonadal testosterone levels has not been assessed in the primary care setting in Europe, we aimed to investigate the prevalence of low testosterone levels in this setting, and the patient characteristics and comorbidities associated with it.Methods: We measured testoster...

Objectives: Acromegaly is associated with elevated cardiovascular morbidity. Medical treatment of acromegaly does not only lead to a normalisation of the somatotroph axis, but can also negatively influence cardiovascular risk factors and comorbidities.Methods: In a cross-sectional study, we evaluated cardiovascular risk markers (glucose, HbA1c, triglycerides, cholesterol, HDL, LDL, lipoprotein a, homocystein, CRP) in relation to biochemical control and m...

Background: In acromegaly, few in vivo data exist on changes of the brain parenchyma as a pathology caused by systemically elevated levels of GH and IGF-1. This is in contrast to neuropsychiatric symptoms such as depression, cognitive impairment, personality changes and pain syndromes that accompany the condition. We aimed at measuring brain tissue volumes and white matter pathology in acromegaly.Methods: Forty-three patients (age 54±14 years...

Introduction: Transsexualism associates biological normality with the conviction of belonging to the opposite sex and the gender reassignment request. The therapy includes psychological, hormonal and surgical treatment. Only limited clinical studies addressing cross-sex hormonal therapy and side effects exist.Methods: Here, we report the results of a drafted questionnaire evaluating etiological aspects and treatment outcome. The questionnaire was distrib...

Background: Recent studies show that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) are frequent causes of long-term disturbances of hypothalamo–pituitary function. Still little is known about risk factors and clinical characteristics of pituitary impairment after brain damage. This study aimed to address these questions on a larger scale by establishing a national registry of these patients.Methods: All centers treating p...